Endocrine Abstracts

Introduction: Obstructive sleep apnoea (OSA) is reported to have effects on a number of hormone systems including glycaemic control, catecholamines, and the HPA axis. In this study we aimed to determine the impact of OSA on IGF-I levels.Patients & Methods: This is a prospective cohort study performed at Leeds Teaching Hospitals. Patients were recruited from the Sleep Apnoea Clinic between November 2014 and May 2...

Introduction: Obstructive sleep apnoea (OSA) is reported to have effects on a number of hormone systems including glycaemic control, catecholamines, and the HPA axis. In this study we aimed to determine the impact of OSA on IGF-I levels.Patients & Methods: This is a prospective cohort study performed at Leeds Teaching Hospitals. Patients were recruited from the Sleep Apnoea Clinic between November 2014 and May 2...

Introduction: IGF-I is a clinically relevant protein in the diagnosis and monitoring of treatment of growth disorders. The Growth Hormone Research Society and the International IGF Research Society have encouraged the adoption of a universal calibration for immunoassays to improve standardization of IGF-I measurements.Objectives: Comparison of new standardization IGF-I assay with IGF-I assay currently used in CHLC, Lisbon; To study whether the introducti...

Background: The GH/IGF-I axis has been implicated in the development of breast cancer. However the regulation of local expression of the GH/IGF-I axis in breast tissue is unknown. In vitro studies have suggested an inhibitory effect of ghrelin on the proliferation of breast cancer cell lines, although the mechanisms for this action are unknown.Aims: Using a physiologically relevant culture system for breast tissue explants, to investigate the effects of ...

Type 1 deiodinase (D1) catalyses synthesis of triiodothyronine (T3) which regulates the expression of many tumor suppressor genes and oncogenes. We previously revealed that the expression of the whole pool of D1 transcripts was dramatically lowered in ccRCC tissues. One of the mechanims resulting in this aberration could be miRNA-mediated repression of target mRNAs. The aim of the study was 1) to analyze the expression of miRNA binding to 3′UTR of D1 in ccRCC; 2) ...

In thyroid cells TSH/cAMP stimulation is associated with proliferation and differentiation. The principal effector of cAMP is the protein kinase A (PKA) and events downstream PKA activation, signaling specificity and expression of PKA isoforms are largely unexplored. PKA is composed of two regulatory and two catalytic subunits. Two major isoforms of PKA (I and II) are determined by their specific regulatory subunits (RIα, RIβ, RIIα and RIIβ). A recent gene ...

Insulin-like growth factor (IGF-I) is an important signal for mammary gland development and epithelial cell survival. Following lactation, the mammary gland undergoes involution through extensive epithelial cell apoptosis and thus, the IGF-I survival signal must be inhibited. IGF actions are regulated by association with high affinity binding proteins (IGFBPs) and the aim of this study was to investigate the expression of IGFBPs during mouse mammary gland development to determ...

Diabetes mellitus is a metabolic disease that is accompanied by brain injury manifested as cognitive, emotional and vascular impairment.Purpose: To study prevalence and degree of disorders of central nervous system in children with diabetes mellitus type I (TIDM).Objects and methods: Examination of nervous system in 100 children - age 7-18 yrs [9.0-17.8] with TIDM was provided. The control group consisted of healthy children (n...

Introduction: Prolonged elevations of proinflammatory cytokines are associated with sarcopenia muscle wasting (ageing) and in cancer cachexia. Increased activation of the IGF/insulin pathway is an attractive target for combating such wasting.Aims: Using rodent skeletal muscle cell lines we have investigated TNF-α/IGF-I interactions, in an attempt to mimic and understand mechanisms underlying skeletal muscle loss.Methods and re...

Nadir growth hormone (GH) levels after oral glucose tolerance test (OGTT) as well as random insulin-like growth-factor I (IGF-I) levels, given as multiples of the upper limit of normal [xULN], were used to evaluate biochemical activitiy of acromegalic patients. The development of new, more sensitive GH assays makes it necessary to reevaluate the cut off values of the GH nadir after OGTT.In a cross sectional study, we evaluated nadir GH concentrations dur...